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Colorectal cancer (CRC) is one of the most frequently occurring forms of solid cancers worldwide in terms of absolute number of new cases per year. It is strongly related to lifestyle factors, representing over half of all gastrointestinal cancer deaths. The epidemic of obesity and physical inactivity has great impact on the pattern of this disease, with altered metabolism being directly implicated in cancer initiation and growth. Substantial progress has been made in colorectal cancer in the past decade, even though patient compliance with screening recommendations remains poor. At the same time, there is greater understanding of the genetic basis of inherited colorectal cancer and identification of patients at risk. More than a fifth of patients with colorectal cancer might have a familial component, and about 3% of all cases will develop Lynch syndrome, which is the most common hereditary syndrome associated with this cancer. Inflammation is a critical component, with colorectal cancer arising from sites of chronic irritation and infection.
Clinical pearls:
Biochemical and pathophysiological considerations
Epidemiology
Inflammatory mediators
The correlation between intake vitamin B6, vitamin D, probiotics and colorectal cancer
Botanicals inhibiting cell proliferation and inducing apoptosis in colorectal cancer cells
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